ML291

ML291 is a UPR (unfolded protein response) -inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].

Product Specifications

CAS Number

[1523437-16-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Eukaryotic Initiation Factor (eIF) ; PERK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ml291.html

Purity

99.80

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(S(=O)(N3CCC(Cl)CC3)=O)C=C2

Molecular Formula

C16H16ClN3O6S

Molecular Weight

413.83

Precautions

H315, H319, H335

References & Citations

[1]Danielle Garshott, et al. The Novel Sulfonamidebenzamide ML291 Activates Apoptotic UPR Signaling in Pediatric Leukemia. Blood. 2016,128 (22) :3523.