Glucosylsphingosine

Glucosylsphingosine (lyso-Gb1) is a deacylated form of glucosylceramide with neurotoxicity and is also a noncompetitively inhibitor of glucocerebrosidase with a Ki value of 30 μM. Glucosylsphingosine is promising for research of Krabbe and Gaucher disease[1][2][3][4][5][6].

Product Specifications

CAS Number

[52050-17-6]

Product Name Alternative

Glucopsychosine; Lyso-Gb1; Lyso-GL1

UNSPSC

12352005

Target

Drug Metabolite; Glycosidase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glucosylsphingosine.html

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC

Molecular Formula

C24H47NO7

Molecular Weight

461.63

References & Citations

[1]Hurvitz N, et al. Glucosylsphingosine (lyso-Gb1) as a Biomarker for Monitoring Treated and Untreated Children with Gaucher Disease. Int J Mol Sci. 2019 Jun 21;20 (12) :3033.|[2]Dekker N, et al. Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response. Blood. 2011 Oct 20;118 (16) :e118-27. |[3]Schueler UH, et al. Toxicity of glucosylsphingosine (glucopsychosine) to cultured neuronal cells: a model system for assessing neuronal damage in Gaucher disease type 2 and 3. Neurobiol Dis. 2003 Dec;14 (3) :595-601.|[4]Stahl-Meyer K, et al. Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells. PLoS One. 2022 Nov 21;17 (11) :e0277058. |[5]Atsumi S, et al. Accumulation of tissue glucosylsphingosine in Gaucher-like mouse induced by the glucosylceramidase inhibitor cyclophellitol. Arch Biochem Biophys. 1993 Jul;304 (1) :302-4. |[6]Lukas J, et al. Glucosylsphingosine Causes Hematological and Visceral Changes in Mice-Evidence for a Pathophysiological Role in Gaucher Disease. Int J Mol Sci. 2017 Oct 20;18 (10) :2192.