PD-089828
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 μM) . PD-089828 also inhibits MAPK with an IC50 of 7.1 μM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity[1].
Product Specifications
CAS Number
179343-17-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
EGFR; FGFR; PDGFR; Src
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-089828.html
Purity
98.07
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=C(Cl)C=CC=C3Cl
Molecular Formula
C18H18Cl2N6O
Molecular Weight
405.28
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; PDGFRβ
Available Sizes
Frequently Asked Questions
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