IL-10R alpha, Human (HEK293, His-Avi)
IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His-Avi) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a His and Avi tag at the C-terminus[1].
Product Specifications
Product Name Alternative
IL-10R alpha Protein, Human (HEK293, His-Avi), Human, HEK293
UNSPSC
12352202
Type
Recombinant Proteins
Assay Protocol
https://www.medchemexpress.com/cytokines/il-10r-alpha-protein-human-hek293-his-avi.html
Purity
95.0
Molecular Formula
3587 (Gene_ID) Q13651 (H22-N235) (Accession)
Molecular Weight
40-48 kDa
References & Citations
[1]Dror S Shouval, et al. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol. 2014;122:177-210.|[2]J Shi, et al. IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. Cell Death Dis. 2016 Mar 10;7 (3) :e2133.|[3]L Crepaldi, et al. Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10. J Immunol. 2001 Aug 15;167 (4) :2312-22.|[4]Nianci Chen, et al. Targeting of IL-10R on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells. Blood Cancer J. 2021 Aug 14;11 (8) :144.|[5]Douglas J Kominsky, et al. IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J Immunol. 2014 Feb 1;192 (3) :1267-76.
Shipping Conditions
Room temperature in continental US; may vary elsewhere.
Storage Conditions
Stored at -20°C for 2 years
Scientific Category
Recombinant Proteins
Available Sizes
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