GSA-10
GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development[1][2][3].
Product Specifications
CAS Number
300833-95-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Hedgehog; Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsa-10.html
Purity
98.0
Solubility
DMSO : 1.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(OCCC)C1=CC=C(NC(C2=C(O)C3=C(N(CCCCCC)C2=O)C=CC=C3)=O)C=C1
Molecular Formula
C26H30N2O5
Molecular Weight
450.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol. 2013 May;83 (5) :1020-9. |[2]Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H) -quinolone derivatives. Eur J Med Chem. 2016 Oct 4;121:747-757. |[3]Fleury A, et al. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep. 2016 Mar 24;6:23479. doi: 10.1038/srep23479. PMID: 27010359; PMCID: PMC4806302.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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