GSA-10

GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development[1][2][3].

Product Specifications

CAS Number

[300833-95-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Hedgehog; Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsa-10.html

Purity

98.0

Solubility

DMSO : 1.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OCCC)C1=CC=C(NC(C2=C(O)C3=C(N(CCCCCC)C2=O)C=CC=C3)=O)C=C1

Molecular Formula

C26H30N2O5

Molecular Weight

450.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol. 2013 May;83 (5) :1020-9. |[2]Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H) -quinolone derivatives. Eur J Med Chem. 2016 Oct 4;121:747-757. |[3]Fleury A, et al. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep. 2016 Mar 24;6:23479. doi: 10.1038/srep23479. PMID: 27010359; PMCID: PMC4806302.