Apramycin (sulfate)

Apramycin (EBL 1003) sulfate is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin sulfate is a potential anti-drug-resistance antibiotic[1][2][3].

Product Specifications

CAS Number

[65710-07-8]

Product Name Alternative

Nebramycin II (sulfate)

UNSPSC

12352005

Hazard Statement

H360

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Apramycin-sulfate.html

Purity

98.0

Solubility

H2O : ≥ 200 mg/mL

Smiles

O[C@H]1[C@](O[C@H](O[C@@]([C@H](C[C@H]2N)N)([H])[C@@H]([C@H]2O)O)[C@H](N)C3)([H])[C@@]3([H])O[C@H](O[C@@]([C@@H]([C@@H](O)[C@@H]4N)O)([H])O[C@@H]4CO)[C@H]1NC.O=S(O)(O)=O

Molecular Formula

C21H43N5O15S

Molecular Weight

637.66

Precautions

H360

References & Citations

[1]Juhas M, et al. In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii. J Antimicrob Chemother. 2019;74 (4) :944-952.|[2]Meyer M, et al. In vivo efficacy of apramycin in murine infection models. Antimicrob Agents Chemother. 2014 Nov;58 (11) :6938-41.|[3]Becker K, et al. Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis. EBioMedicine. 2021 Nov;73:103652.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Phase 1

Isoform

Aminoglycoside

Citation 01

Acta Pharm Sin B. 2023 Sep;13 (9) :3678-3693.|Nat Microbiol. 2023 Mar;8 (3) :410-423.|Nat Microbiol. 2025 Nov;10 (11) :2875-2891.|J Adv Res. 2024 Jun 27:S2090-1232 (24) 00256-X.