Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

LB-100

LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells[1][2][3].

Product Specifications

CAS Number

1632032-53-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LB-100.html

Concentration

10mM

Purity

99.77

Solubility

H2O : ≥ 48 mg/mL

Smiles

O=C(N(CC1)CCN1C)C2[C@@](CC3)([H])O[C@@]3([H])C2C(O)=O

Molecular Formula

C13H20N2O4

Molecular Weight

268.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Bai X, et al. Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis. Cancer Lett. 2014 Oct 7. pii: S0304-3835 (14) 00589-8.|[2]Bai XL, et al. Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas. Mol Cancer Ther. 2014 Aug;13 (8) :2062-72.|[3]Fu QH, et al. LB-100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. Tumour Biol. 2016 Jun;37 (6) :7277-8

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Mouse Clcn4 activation kit by CRISPRa
GA200747 1 Kit

Mouse Clcn4 activation kit by CRISPRa

Sign In for Pricing
View Details
AKT1 (C-term) (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 5C10]
AM00110PU-N 100 µg

AKT1 (C-term) (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 5C10]

Sign In for Pricing
View Details
Human ZNF467 activation kit by CRISPRa
GA116176 1 Kit

Human ZNF467 activation kit by CRISPRa

Sign In for Pricing
View Details
NDUFB2 Rabbit Monoclonal Antibody [Clone ID: R03-7G4]
TA421471 100 µL

NDUFB2 Rabbit Monoclonal Antibody [Clone ID: R03-7G4]

Sign In for Pricing
View Details
EVC Polyclonal Antibody
E-AB-90434-01 60 µL

EVC Polyclonal Antibody

Sign In for Pricing
View Details
EVC Polyclonal Antibody
E-AB-90434-02 120 µL

EVC Polyclonal Antibody

Sign In for Pricing
View Details