Triamterene

Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor[1][2].

Product Specifications

CAS Number

[396-01-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

G protein-coupled Bile Acid Receptor 1; Sodium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/triamterene.html

Purity

99.90

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC(N)=C2N=C(C3=CC=CC=C3)C(N)=NC2=N1

Molecular Formula

C12H11N7

Molecular Weight

253.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432 (5) : p. 760-6.|[2]Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25 (2) : p. 237-41.|[3]Shafaroodi H, et al. A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice. Epilepsy Res. 2016 Mar;121:8-13.|[4]Devane J, et al. The effects of amiloride and triamterene on urinary magnesium excretion in conscious saline-loaded rats. Br J Pharmacol. 1981 Feb;72 (2) :285-9.|[5]Moghadam NH, et al. In vitro cytotoxicity and DNA/HSA interaction study of triamterene using molecular modelling and multi-spectroscopic methods. J Biomol Struct Dyn. 2019 Jun;37 (9) :2242-2253.|[6]Park NY, et al. Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity. Arch Pharm Res. 2021 Jun;44 (6) :621-631.|[7]Daleau P, et al. Triamterene inhibits the delayed rectifier potassium current (IK) in guinea pig ventricular myocytes. Circ Res. 1994 Jun;74 (6) :1114-20.