Epirubicin
Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase[1]. Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity[2].
Product Specifications
CAS Number
[56420-45-2]
Product Name Alternative
4'-Epidoxorubicin
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Antibiotic; Apoptosis; DNA/RNA Synthesis; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/epirubicin.html
Concentration
10mM
Purity
99.11
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C(O)=C3[C@@H](O[C@@]4([H])C[C@H](N)[C@@H](O)[C@H](C)O4)C[C@@](C(CO)=O)(O)CC3=C1O)C5=CC=CC(OC)=C5C2=O
Molecular Formula
C27H29NO11
Molecular Weight
543.52
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Topoisomerase
Citation 01
Available Sizes
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