EI1
EI1 (KB-145943) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
Product Specifications
CAS Number
[1418308-27-6]
Product Name Alternative
KB-145943
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ei1.html
Concentration
10mM
Purity
99.78
Solubility
DMSO : 7.69 mg/mL (ultrasonic)
Smiles
CCC(CC)N(C=C1)C2=C1C(C(NCC3=C(C)C=C(C)NC3=O)=O)=CC(C#N)=C2
Molecular Formula
C23H26N4O2
Molecular Weight
390.48
Precautions
P264-P270-P330-P501
References & Citations
[1]Qi W, et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A. 2012 Dec 26;109 (52) :21360-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2
Available Sizes
Curated Selection
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