Piroxicam cinnamate

Piroxicam cinnamate (Cinnoxicam) is a cyclooxygenase (COX) inhibitor, with anti-inflammatory activity. Piroxicam cinnamate is stable under gastric conditions, can be used for inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele (VC) associated oligoasthenospermia research[1][2][4].

Product Specifications

CAS Number

[87234-24-0]

Product Name Alternative

Cinnoxicam; SPA-S-510; Sinartol

UNSPSC

12352005

Hazard Statement

H302, H373

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/piroxicam-cinnamate.html

Concentration

10mM

Purity

99.19

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(/C=C/C1=CC=CC=C1)OC(C2=CC=CC=C23)=C(C(NC4=CC=CC=N4)=O)N(C)S3(=O)=O

Molecular Formula

C24H19N3O5S

Molecular Weight

461.49

Precautions

H302, H373

References & Citations

[1]Poli G, et al. The Role of NLRP3 Inflammasome Activation and Oxidative Stress in Varicocele-Mediated Male Hypofertility. Int J Mol Sci. 2022 May 7;23 (9) :5233. |[2]Cavallini G, et al. Medical therapy of oligoasthenospermia associated with left varicocele. BJU Int. 2003 Apr;91 (6) :513-8. |[3]Berti M, et al. [Correlation of the lipophilicity of the active agents with their topical anti-inflammatory activity]. Bollettino Chimico Farmaceutico, 1992, 131 (7) :270-273. |[4]M Nakka, et al. Synthesis, characterization and anti-bacterial screening of Piroxicam based sulfonates. J. Chem. Pharm. Res., 2011, 3 (2) :581-588.