GW 848687X

GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain[1].

Product Specifications

CAS Number

[612831-24-0]

UNSPSC

12352005

Hazard Statement

H225-H319-H336

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/gw-848687x.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC(C2=C(CCC2)C3=C(OCC4=CC=C(C=C4F)F)C=CC(Cl)=C3)=N1)O

Molecular Formula

C24H18ClF2NO3

Molecular Weight

441.85

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Giblin GM, et al. The discovery of 6-[2- (5-chloro-2-{[ (2,4-difluorophenyl) methyl]oxy}phenyl) -1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2007 Jan 15;17 (2) :385-9.