Canine IL-33 Recombinant Protein

IL-33 (Interleukin 33) is a member of the IL-1 family that potently drives production of T helper-2 (Th2) -associated cytokines (e.g., IL-4) . It is expressed by a wide variety of cell types, including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells, and epithelial cells. IL-33 acts intracellularly as a nuclear factor and extracellularly as a cytokine. As a cytokine, IL-33 interacts with the receptors ST2 (also known as IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells.

SIQEYSASLS TYNDQSITFV FEDGSYEIYV EDLRKGQEKD KVLFRYYDSQ SPSHETGDDV DGQTLLVNLS PTKDKDFLLH ANNEEHSVEL QKCENQLPDQ AFFLLHRKSS ECVSFECKNN PGVFIGVKDN HLALIKVGDQ TKDSYIEKTI FKLS (154)