Feline SCF (Stem Cell Factor) Recombinant Protein

SCF (stem cell factor), often known as Kit Ligand, KITL or KITLG, is involved in pathways that control the regulation of cell survival, migration and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, and melanogenesis. The SCF of most vertebrates has a soluble form as well as the membrane bound type I receptor form. Mutations in the SCF pathway may result in a broad range of abnormalities including anemia, and sterility. SCF and KIT interaction has been shown to promote the growth of cancer cells and organoids in culture, and xenograft tumors in mice. SCF is being utilized in many animal model systems, from metastasis research in breast tumor-bearing arthritic mice to the genetic linkage to de-pigmentation in pigs. Interestingly, a second SCF pathway was retained in zebrafish, after a whole genome duplication, and is now undergoing divergent evolution.

GLCRNRVTDD VKDVTKLVAN LPKDYKIALK YVPGMDVLPS HCWISVMVEQ LSVSLTDLLD KFSNISEGLS NYSIIDKLVK IVDDLVECVE GHSSENVKKS SKSPEPRLFT PEEFFRIFNR SIDAFKDLEM VASKTSECVV SSTLSPEKDS RVSVTKPFML PPVAASSLRN DSSSSNRKAT NPIEDSSIQW AVMALPACFS LVIGFAFGAF YWKKKQPNLT RTVENIQINE EDNEISMLQE KEREFQEV (248)

Acinonyx jubatus (cheetah), Felis catus (domestic cat), Leopardus geoffroyi (Geoffroy's cat), Lynx rufus (bobcat), Neofelis nebulosa (Clouded leopard), Panthera leo (lion), Panthera onca (jaguar), Panthera pardus (leopard), Panthera tigris (tiger), Panthera tigris altaica (Amur tiger), Prionailurus bengalensis (leopard cat), Prionailurus viverrinus (fishing cat)