Dolphin TIM-3 Recombinant Protein

The Dolphin TIM-3 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Dolphin TIM-3 applications are for cell culture, ELISA standard, and Western Blot Control. Dolphin TIM-3 yeast-derived recombinant protein can be purchased in multiple sizes. Dolphin TIM-3 Specifications: (Molecular Weight: 18.6 kDa) (Amino Acid Sequence: VYVSEVGQDA DLPCAYSPPT PEDLVPVCWG KGPCPLFQCH SLVLSTDGRN LSYWTSSRYL LKRNFRKGDV TLTIKNVTLE DSGTYCCRIQ FPGLMNDQKS NLELVIKPAK VTPAGTPWRD ITAAFPRMLT TEGPGSETQT LETLHDKNQT EISTLANELQ DMGATTRI (168) ) (Gene ID: 101331594) . For research use only.

Product Specifications

Background

TIM-3 is a transmembrane protein of T lymphocytes (CD4+ and CD8+ T cells), myeloid cells (monocytes, macrophages, DC, mast cells, NK cells) or various cells in different tumor types. The receptor is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8+ T-cell exhaustion in terms of proliferation and secretion of cytokines such as TNF-alpha, IFN-gamma and IL-2.