Human CCL17 Recombinant Protein

The Human CCL17 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Human CCL17 applications are for cell culture, ELISA standard, and Western Blot Control. Human CCL17 yeast-derived recombinant protein can be purchased in multiple sizes. Human CCL17 Specifications: (Molecular Weight: 8.0 kDa) (Amino Acid Sequence: ARGTNVGREC CLEYFKGAIP LRKLKTWYQT SEDCSRDAIV FVTVQGRAIC SDPNNKRVKN AVKYLQSLER S) . For research use only.

Product Specifications

Background

CCL17 was initially named TARC is a member of the C-C family of chemokines. CCL17 as well as its partner chemokine CCL22 induce chemotaxis in T-helper cells. It is one of the few chemokines that are not stored in the body, except in the thymus; these chemokines are made when needed by dendritic cells, macrophages, and monocytes. CCL17 is expressed constitutively in the thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It can also be detected in other tissues such as the colon, small intestine, and lung. Granulocyte-macrophage colony-stimulating factor (GM-CSF) upregulates CCL17 production in monocytes and macrophages. Dendritic cells will produce large quantities of CCL17 when stimulated with IL-4 or TSLP.