Swine Leukemia Inhibitory Factor (LIF) Recombinant Protein

The Swine LIF yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Swine LIF applications are for cell culture, ELISA standard, and Western Blot Control. Swine LIF yeast-derived recombinant protein can be purchased in multiple sizes. Swine LIF Specifications: (Molecular Weight: 19.7 kDa) (Amino Acid Sequence: SPLSITPVNA TCATRHPCHS NLMNQIKNQL AQLNSSANAL FILYYTAQGE PFPNNLDKLC GPNVTNFPPF HANGTEKARL VELYRIIAYL GASLGNITRD QRSLNPGAVN LHSKLNATAD SMRGLLSNVL CRLCNKYHVA HVDVAYGPDT SGKDVFQKKK LGCQLLGKYK QVISVLARAF (180) ) (Gene ID: 399503) . For research use only.

Product Specifications

Background

Leukemia inhibitory factor, or LIF, is a member of the IL-6 family. LIF affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. Leukemia inhibitory factor derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to LIF include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. p53 regulated LIF has been shown to facilitate implantation in the mouse model and possibly in humans. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. LIF is typically added to stem cell culture medium to reduce spontaneous differentiation.