Multi-species (Human, Monkey) CD40 Ligand (TNFSF5) Recombinant Protein

CD40 Ligand (CD40LG) is a transmembrane protein that is a member of the TNF superfamily. In addition to existing in a membrane bound form, CD40LG can also be released as a soluble molecule (sCD40LG), which has been shown to have biological functions. CD40 interacts with CD40 ligand, which is predominantly expressed on activated CD4+ T-cells. CD40LG is transiently expressed on activated T-cells and plays a crucial role in B-cell function. Activated T-cells expressing CD40LG can also interact with CD40 on endothelial cells to induce production of inflammatory cytokines. The transient expression of CD40LG allows T-cells to stimulate selected CD40-bearing cells to participate in the immune response. Increased levels of sCD40LG have been measured in patients with SLE, RA, inflammatory bowel diseases, systemic sclerosis, and Sjogren's syndrome.

Aotus nancymaae (Ma's night monkey), Cercocebus atys (sooty mangabey), Chlorocebus sabaeus (green monkey), Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human), Macaca fascicularis (Cynomolgus monkey), Macaca mulatta (Rhesus monkey), Macaca nemestrina (pig-tailed macaque), Mandrillus leucophaeus (drill), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee), Papio anubis (olive baboon), Pongo abelii (Sumatran orangutan)