Rat EGF Recombinant Protein

The Rat EGF yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Rat EGF applications are for cell culture, ELISA standard, and Western Blot Control. Rat EGF yeast-derived recombinant protein can be purchased in multiple sizes. Rat EGF Specifications: (Molecular Weight: 5.4 kDa) (Amino Acid Sequence: NSITGCPPSY DGYCLNGGVC MYVESVDRYV CNCVIGYIGE RCQHRDLR (48) ) (Gene ID: 25313) . For research use only.

Product Specifications

Background

EGF (Epidermal Growth Factor) is best known for having the ability to stimulate cell growth and proliferation. There are many EGF responses and they are regulated by seven ligands: EGF, transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN) and four ErbB (HER) family receptor tyrosine kinases: EGFR/ErbB1, ErbB2, ErbB3 and ErbB4. EGF family members are important for development and promoting mitogenesis and differentiation of mesenchymal and epithelial cells. EGF acts as a mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. EGF plays a significant role in epithelial development, angiogenesis, regulation of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture. EGF dysregulation is also associated with the growth and progression of many cancers.