Bovine Placental Growth Factor (PlGF) Recombinant Protein

Placental growth factor (PlGF) is a member of the VEGF (vascular endothelial growth factor) family and a key molecule in angiogenesis and vasculogenesis especially during embryogenesis. PlGF is redundant for vascular development and physiologic vessel maintenance in healthy human adults and maintenance but contributes to the angiogenic and inflammatory switch in various diseases, including tumor growth, ischemia, and chronic inflammation. Many cell types express PlGF in pathologic conditions, including endothelial cells, smooth muscle cells, fibroblasts, leukocytes, and bone marrow progenitors. PlGF is readily upregulated in pathologic conditions by various stimuli, such as hypoxia, nitric oxide, inflammatory cytokines (e.g. interleukin 1 and TNF-α), and growth factors (e.g. VEGF-A and transforming growth factor-β) .