Multi-species CXCL12 (Bat, Dolphin, Feline, Guinea Pig, Human, Mink, Monkey) (SDF-1) Recombinant Protein

CXCL12 (formerly stromal cell-derived factor 1) was originally described as a vital chemoattractant for B cells and monocytes. CXCL12 is unlike other chemokines in that it binds to one single chemokine receptor, CXCR4, which itself is recognized by no other chemokines. CXCL12 binds to its receptor CXCR4 to mediate cell-type specific physiological processes including cellular migration, survival, and apoptosis. CXCL12 is produced physiologically in various tissues and its receptor CXCR4 is also expressed on various haematopoietic and non-haematopoietic cells. CXCL12 and CXCR4 are essential for life as mice deficient in either gene are unable to survive much past birth. CXCL12 and CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis.

Acinonyx jubatus (cheetah), Aotus nancymaae (Ma's night monkey), Apodemus sylvaticus (European woodmouse), Artibeus jamaicensis (Jamaican fruit-eating bat), Arvicanthis niloticus (Nile rat), Balaenoptera acutorostrata (minke whale), Balaenoptera musculus (blue whale), Callithrix jacchus (white-tufted-ear marmoset), Carlito syrichta (Philippine tarsier), Cavia porcellus (domestic guinea pig), Cebus imitator (Panamanian white-faced capuchin), Chlorocebus sabaeus (Cercopithecus sabaeus), Choloepus didactylus (southern two-toed sloth), Dasypus novemcinctus (nine-banded armadillo), Delphinapterus leucas (beluga whale), Delphinus delphis (saddleback dolphin), Desmodus rotundus (common vampire bat), Echinops telfairi (small Madagascar hedgehog), Enhydra lutris kenyoni (northern sea otter), Eubalaena glacialis (North Atlantic right whale), Felis catus (domestic cat), Globicephala melas (long-finned pilot whale), Gorilla gorilla gorilla (western lowland gorilla), Gulo gulo luscus (American wolverine), Homo sapiens (human), Hyaena hyaena (striped hyena), Hylobates moloch (silvery gibbon), Kogia breviceps (pygmy sperm whale), Lagenorhynchus albirostris (white-beaked dolphin), Lagenorhynchus obliquidens (Pacific white-sided dolphin), Leopardus geoffroyi (Geoffroy's cat), Lipotes vexillifer (Yangtze River dolphin), Lontra canadensis (Northern American river otter), Lutra lutra (Eurasian river otter), Lynx canadensis (Canada lynx), Macaca fascicularis (crab-eating macaque), Macaca mulatta (Rhesus monkey), Macaca nemestrina (pig-tailed macaque), Meles meles (Eurasian badger), Mesoplodon densirostris (Blainville's beaked whale), Monodon monoceros (narwhal), Nannospalax galili (Upper Galilee mountains blind mole rat), Neofelis nebulosa (Clouded leopard), Neogale vison (American mink), Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise), Nomascus leucogenys (northern white-cheeked gibbon), Orcinus orca (killer whale), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee), Panthera leo (lion), Panthera onca (jaguar), Panthera pardus (leopard), Panthera tigris (tiger), Panthera uncia (snow leopard), Papio anubis (olive baboon), Phocoena phocoena (harbor porpoise), Phocoena sinus (vaquita), Phyllostomus discolor (pale spear-nosed bat), Physeter catodon (sperm whale), Piliocolobus tephrosceles (Ugandan red Colobus), Pongo abelii (Sumatran orangutan), Pongo pygmaeus (Bornean orangutan), Prionailurus bengalensis (leopard cat), Prionailurus viverrinus (fishing cat), Puma yagouaroundi (jaguarundi), Rhinopithecus bieti (black snub-nosed monkey), Rhinopithecus roxellana (golden snub-nosed monkey), Rousettus aegyptiacus (Egyptian rousette), Saimiri boliviensis boliviensis (Bolivian squirrel monkey), Sapajus apella (tufted capuchin), Sturnira hondurensis (Honduran Yellow-shouldered Bat), Suricata suricatta (meerkat), Theropithecus gelada (gelada), Trachypithecus francoisi (Francois's langur), Tupaia chinensis (Chinese tree shrew), Tursiops truncatus (common bottlenose dolphin)