Rabbit IL-6 Recombinant Protein

The Rabbit IL-6 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Rabbit IL-6 applications are for cell culture, ELISA standard, and Western Blot Control. Rabbit IL-6 yeast-derived recombinant protein can be purchased in multiple sizes. Rabbit IL-6 Specifications: (Molecular Weight: 24.5 kDa) (Amino Acid Sequence: FPTSAPVRED SNTKASPDKT LTPPGRTIES IRSILETIKE LRKEMCDHDV NCMNRKEALA EVNLHLPRLI EEDGCFPPAV NNETCLLRIT SGLMEFRMYL EHLQAKFRSD EENTRVSMVL KNIQHLIKTL RPKVKNLNEE ATLKPAVAVS LMENLQQKNQ WLKTTTIHFI LRGLTNFLEF TLRAVDLM (188) ) (Gene ID: 100008733) . For research use only.

Product Specifications

Background

IL-6 acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. The role of IL-6 as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.