Human IL-18 Recombinant Protein

The Human IL-18 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Human IL-18 applications are for cell culture, ELISA standard, and Western Blot Control. Human IL-18 yeast-derived recombinant protein can be purchased in multiple sizes. Human IL-18 Specifications: (Molecular Weight: 18.2 kDa) (Amino Acid Sequence: YFGKLESKLS VIRNLNDQVL FIDQGNRPLF EDMTDSDCRD NAPRTIFIIS MYKDSQPRGM AVTISVKCEK ISTLSCENKI ISFKEMNPPD NIKDTKSDII FFQRSVPGHD NKMQFESSSY EGYFLACEKE RDLFKLILKK EDELGDRSIM FTVQNED (157) ) (Gene ID: 3606) . For research use only.

Product Specifications

Background

Interleukin 18 (IL-18), also know an IL-1F4, was isolated as a co-factor that, in synergism with IL-12, stimulated the production of IFN gamma in Th1 cells. It is now understood that IL-18 is an important link between innate and adaptive immune responses and a regulator of both cellular and humoral immunity. IL-18 is secreted in its active form following cleavage by caspase 1 in response to inflammatory and infectious stimuli. In addition to its effects on Th1 cells, IL-18 is a strong stimulator of the activity of natural killer cells alone or in combination with IL-15, and of CD8+ lymphocytes. Together with IL-2, IL-18 can also stimulate the production of IL-13 and of other Th2 cytokines. IL-18 plays a role in numerous inflammatory-associated disorders.

Sequence

YFGKLESKLS VIRNLNDQVL FIDQGNRPLF EDMTDSDCRD NAPRTIFIIS MYKDSQPRGM AVTISVKCEK ISTLSCENKI ISFKEMNPPD NIKDTKSDII FFQRSVPGHD NKMQFESSSY EGYFLACEKE RDLFKLILKK EDELGDRSIM FTVQNED (157)