Cynomolgus Monkey IL-10 Recombinant Protein

IL-10 has multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29. These cytokines elicit diverse host defense mechanisms. IL-10 family cytokines are essential for maintaining the integrity and homeostasis of tissue epithelial layers. By promoting inamte immune response, members of this family can limit the damage caused by viral and bacterial infections. They can also facilitate the tissue-healing process in injuries caused by infection or inflammation. IL-10 itself is an anti-inflammatory cytokine. IL-10 family cytokines have indispensable functions in many infectious and inflammatory diseases.

Cercocebus atys (sooty mangabey), Chlorocebus sabaeus (green monkey), Macaca fascicularis (crab-eating macaque), Macaca mulatta (Rhesus monkey), Mandrillus leucophaeus (drill), Papio hamadryas (hamadryas baboon)