Mouse CXCL12 (SDF-1) Recombinant Protein

CXCL12 (formerly stromal cell-derived factor 1) was originally described as a vital chemoattractant for B cells and monocytes. CXCL12 is unlike other chemokines in that it binds to one single chemokine receptor, CXCR4, which itself is recognized by no other chemokines. CXCL12 binds to its receptor CXCR4 to mediate cell-type specific physiological processes including cellular migration, survival, and apoptosis. CXCL12 is produced physiologically in various tissues and its receptor CXCR4 is also expressed on various haematopoietic and non-haematopoietic cells. CXCL12 and CXCR4 are essential for life as mice deficient in either gene are unable to survive much past birth. CXCL12 and CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis.