Multi-species (Human, Monkey) VEGF-A ELISA

The Human/Monkey VEGF-A ELISA contains capture antibody, standard, and detection antibody for development of a Human/Monkey VEGF-A ELISA. The antibodies have been determined to function in an ELISA with the standard provided. Optimal buffers, concentrations, incubation times, incubation temperatures, and methods for the ELISA have not been determined. This allows for complete flexibility to provide optimal dynamic range and sensitivity based on your sample type. The Human/Monkey VEGF-A ELISA can also be used to measure Sooty Mangabey, Green Monkey, Peter's Angolan Colobus, Western Lowland Gorilla, Rhesus Monkey, Pig-tailed Macaque, Drill, Northern White-cheeked Gibbon, Pygmy Chimpanzee, Chimpanzee, Olive Baboon, and Golden Snub-nosed Monkey VEGF-A. Alternate names include VEGFA, MVCD1, VEGF, VPF, vascular endothelial growth factor A. The quantities of components provided are not matched. Components may also be purchased separately. For research use only.

Product Specifications

Background

VEGF proteins stimulate vasculogenesis and angiogenesis. They are part of the system that restores the oxygen supply to tissues when blood circulation is inadequate. The normal function of VEGF proteins is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels. The VEGF family has six members, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and Placental Growth Factor (PGF) . Activity of VEGF-A, as its name implies, has been studied mostly on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g., stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells) . In vitro, VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor (VPF) .

Homology

Cercocebus atys (sooty mangabey), Chlorocebus sabaeus (green monkey), Colobus angolensis palliates (Peter’s Angolan Colobus), Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human), Macaca fascicularis (Cynomolgus monkey), Macaca mulatta (Rhesus monkey), Macaca nemestrina (pig-tailed macaque), Mandrillus leucophaeus (drill), Nomascus leucogenys (northern white-cheeked gibbon), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee), Papio anubis (olive baboon), Rhinopithecus roxellana (golden snub-nosed monkey)