Canine IL-21 ELISA

The Canine IL-21 ELISA contains capture antibody, recombinant protein standard, and detection antibody for development of a Canine IL-21 ELISA. The antibodies have been determined to function in an ELISA with the standard provided. Optimal buffers, concentrations, incubation times, incubation temperatures, and methods for the ELISA have not been determined. This allows for complete flexibility to provide optimal dynamic range and sensitivity based on your sample type. The Canine IL-21 ELISA can also be used to measure Dingo and Raccoon Dog IL-21. The quantities of components provided are not matched. Components may also be purchased separately. For research use only.

Product Specifications

Background

IL-21 is a member of the type I cytokine family, which includes IL-2 and IL-15. IL-21 signals through the common gamma-chain and a unique IL-21 receptor. The IL-21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL-21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL-21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.