Equine SCF (Stem Cell Factor) Polyclonal Antibody - Biotinylated

The Equine SCF polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Biotech Equine SCF ELISA. The Equine SCF antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Equine SCF - Strong) (Bovine SCF - Weak) (Canine SCF - None) (Canine SCF - None) (Chicken SCF - None) (Feline SCF - Weak) (Human SCF - Weak) (Mouse SCF - None) (Rabbit SCF - None) (Swine SCF - Weak) (Zebra finch SCF - None) . For research use only.

Product Specifications

Background

SCF (stem cell factor), often known as Kit Ligand, KITL or KITLG, is involved in pathways that control the regulation of cell survival, migration and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, and melanogenesis. The SCF of most vertebrates has a soluble form as well as the membrane bound type I receptor form. Mutations in the SCF pathway may result in a broad range of abnormalities including anemia, and sterility. SCF and KIT interaction has been shown to promote the growth of cancer cells and organoids in culture, and xenograft tumors in mice. SCF is being utilized in many animal model systems, from metastasis research in breast tumor-bearing arthritic mice to the genetic linkage to de-pigmentation in pigs. Interestingly, a second SCF pathway was retained in zebrafish, after a whole genome duplication, and is now undergoing divergent evolution.