Dolphin IL-6 Polyclonal Antibody

The Dolphin IL-6 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Dolphin IL-6 ELISA. The Dolphin IL-6 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Atlantic Salmon - None) (Bovine IL-6 - Weak) (Canine IL-6 - None) (Caprine IL-6 - None) (Chicken IL-6 - None) (Cynomolgus Monkey IL-6 - None) (Dolphin IL-6 - Strong) (Equine IL-6 - None) (Feline IL-6 - None) (Human IL-6 - None) (Mouse IL-6 - None) (Ovine IL-6 - Weak) (Rabbit IL-6 - None) (Swine IL-6 - None) (Zebrafish IL-6 - None) . For research use only.

Product Specifications

Background

IL-6 acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. The role of IL-6 as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.

Host

Rabbit

Label

Unconjugated

Applications

ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot

Purification

Antigen-affinity

Homology

Globicephala melas (long-finned pilot whale), Lagenorhynchus obliquidens (Pacific white-sided dolphin), Tursiops truncatus (common bottlenose dolphin)