Bovine Oncostatin M (OSM) Polyclonal Antibody - Biotinylated

The Bovine Oncostatin M (OSM) polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Biotech Bovine Oncostatin M ELISA. The Bovine Oncostatin M antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine OSM - Strong) (Canine OSM - None) (Human OSM - None) (Mouse OSM - None) (Swine OSM - Weak) . For research use only.

Product Specifications

Background

OSM (Oncostatin M) is a secreted cytokine involved in homeostasis and most chronic illnesses. OSM, a member of the IL-6 (gp130) family of proteins, inhibits the proliferation of a number of tumor cell lines and plays a significant role in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism. Of all IL-6-type cytokines studied so far, OSM displays the broadest signaling profile. LIF and OSM proteins activate the JAK/STAT pathway, the MAPK protein kinases ERK1 and ERK2, the stress-activated protein kinases p38 and c-Jun N-terminal kinase (JNK), the phosphatidylinositol-3-kinase (PI3K) AKT pathway and protein kinase C delta (PRKCD) . In addition, OSM exhibits many other effects by regulating the production of other cytokines including IL-6, G-CSF and GM-CSF in endothelial cells. OSM may be a tumor promoter that will provide a potential target for antiangiogenic therapy.