Human Leukemia Inhibitory Factor (LIF) Polyclonal Antibody

The Human LIF polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Human LIF ELISA. The Human LIF antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine LIF - Strong) (Canine LIF - Strong) (Caprine LIF - Strong) (Chicken LIF - None) (Cynomolgus Monkey LIF - Strong) (Dolphin LIF - Strong) (Equine LIF - None) (Feline LIF - Moderate) (Guinea Pig LIF - Moderate) (Human LIF - Strong) (Mouse LIF - Weak) (Rabbit LIF - Moderate) (Rat LIF - Weak) (Swine LIF - Moderate) . For research use only.

Product Specifications

Background

Leukemia inhibitory factor, or LIF, is a member of the IL-6 family. LIF affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. Leukemia inhibitory factor derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to LIF include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. p53 regulated LIF has been shown to facilitate implantation in the mouse model and possibly in humans. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. LIF is typically added to stem cell culture medium to reduce spontaneous differentiation.

Host

Rabbit

Label

Unconjugated

Applications

ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot

Purification

Antigen-affinity

Homology

Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human), Hylobates moloch (silvery gibbon), Nomascus leucogenys (northern white-cheeked gibbon), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee), Pongo abelii (Sumatran orangutan)