Bovine CD40 Ligand (TNFSF5) Polyclonal Antibody

The Bovine CD40 Ligand polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Bovine CD40 Ligand ELISA. The Bovine CD40 Ligand antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CD40 Ligand - Strong) (Canine CD40 Ligand - Moderate) (Chicken CD40 Ligand - None) (Equine CD40 Ligand - Strong) (Feline CD40 Ligand - Strong) (Human CD40 Ligand - Moderate) (Swine CD40 Ligand - Strong) . For research use only.

Product Specifications

Background

CD40 Ligand (CD40LG) is a transmembrane protein that is a member of the TNF superfamily. In addition to existing in a membrane bound form, CD40LG can also be released as a soluble molecule (sCD40LG), which has been shown to have biological functions. CD40 interacts with CD40 ligand, which is predominantly expressed on activated CD4+ T-cells. CD40LG is transiently expressed on activated T-cells and plays a crucial role in B-cell function. Activated T-cells expressing CD40LG can also interact with CD40 on endothelial cells to induce production of inflammatory cytokines. The transient expression of CD40LG allows T-cells to stimulate selected CD40-bearing cells to participate in the immune response. Increased levels of sCD40LG have been measured in patients with SLE, RA, inflammatory bowel diseases, systemic sclerosis, and Sjogren's syndrome.