Human IFN gamma Polyclonal Antibody - Biotinylated

The Human IFN gamma polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Human IFN gamma ELISA. The Human IFN gamma antibody was produced in goats and is antigen-affinity purified. The reactivity by species is: (Bovine IFN gamma - None) (Canine IFN gamma - None) (Caprine IFN gamma - None) (Chicken IFN gamma - None) (Cynomolgus Monkey IFN gamma - Strong) (Dolphin IFN gamma - None) (Equine IFN gamma - None) (Feline IFN gamma - None) (Human IFN gamma - Strong) (Mouse IFN gamma - None) (Ovine IFN gamma - None) (Rabbit IFN gamma - None) (Swine IFN gamma - None) (Zebrafish IFN gamma 1-1 - None) (Zebrafish IFN gamma 1-2 - None) . For research use only.

Product Specifications

Background

IFN gamma is a dimerized soluble cytokine that is the only member of the type II class of interferons. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-γ is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN-γ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-γ in the immune system stems in part from its ability to inhibit viral replication directly, but, most important, derives from its immunostimulatory and immunomodulatory effects. IFN-γ is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.