Cynomolgus Monkey TIM-3 Polyclonal Antibody

The Cynomolgus Monkey TIM-3 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Cynomolgus Monkey TIM-3 ELISA. The Cynomolgus Monkey TIM-3 antibody was produced in rabbits and is antigen-affinity purified. This antibody has shown no cross-reactivity with bat, bovine, dolphin, or mouse TIM-3 proteins. For research use only.

Product Specifications

Background

TIM-3 is a transmembrane protein of T lymphocytes (CD4+ and CD8+ T cells), myeloid cells (monocytes, macrophages, DC, mast cells, NK cells) or various cells in different tumor types. The receptor is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8+ T-cell exhaustion in terms of proliferation and secretion of cytokines such as TNF-alpha, IFN-gamma and IL-2.