Chicken IL-12/IL-23 p40 Polyclonal Antibody

The Chicken IL-12/IL-23 p40 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Chicken IL-12/IL-23 p40 ELISA. The Chicken IL-12/IL-23 p40 polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IL-8 - None) (Canine IL-8 - None) (Dolphin IL-8 - None) (Equine IL-8 - Strong) (Feline IL-8 - Weak) (Guinea Pig IL-8 - None) (Human IL-8 - None) . For research use only.

Product Specifications

Background

IL-12 is a member of the IL-12 family, which includes IL-12, IL-23, IL-27, and IL-35. Like other IL-12 family members, IL-12 is a heterodimeric cytokine. IL-12 is encoded by two separate genes, IL-12A (p35) and IL-12B (p40) . The active heterodimer, and a homodimer of p40 are formed following protein synthesis. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ.