Bovine CD41 Monoclonal Antibody (clone CAPP2A)
CD41 (Integrin Alpha chain 2b) undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals.
Product Specifications
Background
CD41 (Integrin Alpha chain 2b) undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals.
Host
Mouse
Isotype
IgG2a
Applications
Flow Cytometry
Purification
Produced in ascites fluid, clarified by filtration through a 0.2 micrometer filter.
Storage Temperature
2°C to 8°C
Scientific Category
Antibody
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