Swine CTLA-4 Polyclonal Antibody
The Swine CTLA-4 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Swine CTLA-4 ELISA. The Swine CTLA-4 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Swine CTLA-4 - Strong) (Bovine CTLA-4 - None) (Cynomolgus monkey CTLA-4 - None) (Human CTLA-4 - None) (Rabbit CTLA-4 - None) . For research use only.
Product Specifications
Background
CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. It is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.
Host
Rabbit
Label
Unconjugated
Applications
ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
Purification
Antigen-affinity
Homology
Sus scrofa (pig)
Storage Temperature
2°C to 8°C
Scientific Category
Antibody
Available Sizes
Frequently Asked Questions
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