Ovine IL-13 Polyclonal Antibody

The Ovine IL-13 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Ovine IL-13 ELISA. The Ovine IL-13 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IL-13 - Weak) (Canine IL-13 - None) (Caprine IL-13 - Weak) (Chicken IL-13 - None) (Dolphin IL-13 - None) (Equine IL-13 - None) (Human IL-13 - None) (Mouse IL-13 - None) (Ovine IL-13 - Strong) (Rabbit IL-13 - None) (Swine IL-13 - Weak) (Zebrafish IL-13 - None) . For research use only.

Product Specifications

Background

IL-13 is secreted by many cell types, but especially T helper type 2 (Th2) cells. IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. Thus, although IL-13 can induce immunoglobulin E (IgE) secretion from activated human B cells, deletion of IL-13 from mice does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by potent allergens.