Multi-species (Zebrafish, Stickleback) IL-4 Polyclonal Antibody - Biotinylated

The Zebrafish IL-4 polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Zebrafish IL-4 ELISA. The Zebrafish IL-4 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Atlantic Salmon IL-4-13 - None) (Bat IL-4 - None) (Bovine IL-4 - None) (Canine IL-4 - None) (Caprine IL-4 - None) (Chicken IL-4 - None) (Cynomolgus Monkey - None) (Dolphin IL-4 - None) (Equine IL-4 - None) (Feline IL-4 - None) (Ferret IL-4 - None) (Human IL-4 - None) (Mallard IL-4 - None) (Mouse IL-4 - None) (Ovine IL-4 - None) (Rabbit IL-4 - None) (Rat IL-4 - None) (Swine IL-4 - None) (Zebrafish IL-4 - Strong) . For research use only.

Product Specifications

Background

IL-4 induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. Overproduction of IL-4 is associated with allergies.