Multi-species (Ferret, Mink) CXCL10 (IP-10) Polyclonal Antibody

The Ferret/Mink CXCL10 (IP-10) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Ferret CXCL10 ELISA. The Ferret CXCL10 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CXCL10 - Weak) (Canine CXCL10 - None) (Caprine CXCL10 - None) (Cynomolgus Monkey CXCL10 - None) (Dolphin CXCL10 - Moderate) (Equine CXCL10 - None) (Feline CXCL10 - Moderate) (Ferret CXCL10 - Strong) (Guinea Pig CXCL10 - None) (Human CXCL10 - None) (Mouse CXCL10 - None) (Ovine CXCL10 - Weak) (Rabbit CXCL10 - None) (Rat CXCL10 - None) (Swine CXCL10 - Moderate) . For research use only.

Product Specifications

Background

CXCL10, also known as Interferon gamma-induced protein 10 or small-inducible cytokine B10, is a member of the C-X-C chemokine family. CXCL10 is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative) . ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL10 elicits its effects by binding to the cell surface chemokine receptor CXCR3.