Human IL-1 beta Polyclonal Antibody

The Human IL-1 beta polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Human IL-1 beta ELISA. The Human IL-1 beta antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IL-1beta - None) (Canine IL-1beta - None) (Caprine IL-1beta - None) (Cynomolgus Monkey - Weak) (Dolphin IL-1beta - None) (Equine IL-1beta - None) (Feline IL-1beta - None) (Ferret IL-1beta - None) (Guinea Pig IL-1beta - None) (Human IL-1beta - Strong) (Mouse IL-1beta - None) (Ovine IL-1beta - None) (Rabbit IL-1beta - Weak) (Swine IL-1beta - None) (Turkey IL-1beta - None) . For research use only.

Product Specifications

Background

IL-1 beta is produced by activated macrophages, monocytes, and a subset of dentritic cells. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The IL-1 family of cytokines encompasses eleven proteins that each share a similar β-barrel structure and bind to Ig-like receptors. Several of the well characterized members of the IL-1-like cytokines play key roles in the development and regulation of inflammation. IL-1α, IL-1β, and IL-18 (IL-1F4) are well-known inflammatory cytokines active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. In contrast, IL-1 receptor antagonist (IL-1ra; IL-1F3) and IL-36 receptor antagonist (IL-36ra; IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands. IL-33 (IL-1F11) is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. The biological properties of IL-37 (IL-1F7) are mainly those of down-regulating inflammation.