Recombinant Mesocricetus auratus Programmed Cell death 1 ligand 1 isoform X1 (Cd274), partial, Biotinylated

FTITAPKELYEVEYGSNVTIECRFPVKHQLDLLSLVVYWEKNDNPVIQFVDGKVDLKHQHSSFRGRAWLPKEQILKGNAGLQITNVKLQDAGVYGCMISYGGADYKRITLQVNAPYRKINHRISMDPVTSEHELTCQAEGYPEAEVIWTNSDKQSLSDKTTVTISQTEEKLFNVTSTLRINATANDAFYCTFWRLQSGENHTAELIIPEPLAEFLPNKR

The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.