WH-15
WH-15 is a fluorogenic PLC reporter with Km value of 49; 30, 86.1 µM for PLC-γ1, PLC-δ1, PLC-β2, respectively. WH-15 can be cleaved in a cascade reaction to generate fluorescent 6-aminoquinoline. WH-15 can be used to respond to imaging PLC activity in live cells (Ex/Em = ~344/530 nm) [1].
Product Specifications
CAS Number
[1264748-47-1]
UNSPSC
12171500
Target
Phospholipase
Type
Dye Reagents
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/wh-15.html
Purity
99.51
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@H](OP(O)(OC2=CC=C(COC(NC3=CC=C4N=CC=CC4=C3)=O)C=C2OCCCCCCCC)=O)[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1O
Molecular Formula
C31H43N2O18P3
Molecular Weight
824.60
References & Citations
[1]Huang W, et al. A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes. ACS Chem Biol. 2011 Mar 18;6 (3) :223-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
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