Recombinant Human Claudin-18.2 (CLDN18.2) -Detergent (Active)
Product Specifications
Product Name Alternative
(CLDN18.2)
Abbreviation
Recombinant Human CLDN18.2 protein-Detergent (Active)
Gene Name
CLDN18.2
UniProt
P56856-2
Expression Region
1-261aa
Organism
Homo sapiens (Human)
Target Sequence
MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
Tag
C-terminal 10xHis-tagged
Type
MP-Detergent Transmembrane Protein & Active Protein & In Stock Protein
Source
Mammalian cell
Field of Research
Signal Transduction
Relevance
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Endotoxin
Not test
Purity
Greater than 80% as determined by SDS-PAGE.
Activity
Yes
Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 5 μg/mL on an Nickel Coated plate can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005505MA1HU), the EC50 is 0.4640-0.6372 ng/mL.
Form
Liquid
Buffer
50 mM HEPES, 0.15 M NaCl, 0.05% DDM, 0.01% CHS, pH7.5
Reconstitution
/
Molecular Weight
29.1 kDa
References & Citations
"Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development." Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tuereci O. Clin. Cancer Res. 14:7624-7634 (2008)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Full Length of Isoform A2
Available Sizes
Frequently Asked Questions
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