SHH, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Sonic HedgeHogrHuShhHhg2Members of the Hedgehog (Hh) family are highly conserved proteins that are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh), are structurally related and share a high degree of amino acid sequence identity. Each Hh protein has a unique expression pattern and distinct biological role within its respective region of secretion. All Hh proteins use the same signaling pathway and can substitute for each other in experimental systems. Shh has been found to have a critical role in development, acting as a morphogen in the patterning of limbs, brain structure, spinal cord, thalamus and the teeth. Shh has been shown to attract commissural axons in the developing spinal cord by attracting or repelling retinal ganglion cell (RGC) axons depending on concentration.Formulation: Sterile filtered white lyophilized powder. Purified and tested for use in cell culture.Sequence: IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKISRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGGMW: ~20.0 kDa (176 amino acid) Purity: >98 % by SDS-PAGE and HPLC analyses.Biological Activity: Fully biologically active when compared to standard. The ED50as determined by inducing alkaline phosphatase production of murine C3H/10T1/2 cells is less than1.0 μg/ml, corresponding to a specific activity of >1.0 x 103IU/mg.Accession Number:Q15465HGNC ID:10848Source:Escherichia coli