PDGFBB (dimer), Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Platelet-derived Growth Factor, Beta Polypeptide (dimer) PDGFABPDGF2Simian Sarcoma Viral Oncogene Homolog (SSV) Oncogene SISBecaplerminPlatelet-derived growth factor (PDGF) is a glycoprotein present in serum but absent from plasma. PDGF has three subforms: PDGFAA, PDGFBB, and PDGF-AB. This form is a disulfide-linked homodimer consisting of two peptide chains B (PDGFBB) . It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. In contrast to PDGFAA, the beta chains in PDGFBB are sufficient for mitogenesis. The function of PDGF is mediated by two tyrosine kinase receptors, PDGFR-α and PDGFR-β, both of which bind PDGFBB.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~24.8 kDa, a disulfide-linked homodimeric protein containing two 110 amino acid residue polypeptides (B chain) Purity: >97% by SDS-PAGE and HPLC analyses.Biological Activity: Fully biologically active when compared to standard. The ED50as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 3 ng/ml, corresponding to a specific activity of >3.3x105IU/mg.