PSPN, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Persephin (PSPN) PSPPersephin (PSPN) belongs to the GDNF ligand subfamily of the TGF-beta superfamily. The amino acid sequence of human PSPN is about 30% analogous to human GDNF. PSPN is synthesized throughout the nervous system and presumably originates from both astroglial cells and neurons. It promotes the survival and growth of mesencephalic dopaminergic and motor neurons. It also plays a role in kidney development by promoting ureteric bud branching. PSPN binds to a receptor complex consisting of Ret tyrosine kinase and GFR-alpha-4.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~20.5 kDa (2x 96 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The ED50as determined by a cell proliferation assay using human TT medullary thyroid cancer cells is less than 10 ng/ml, corresponding to a specific activity of > 1.0 x 105IU/mg.