NRN1, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Neuritin 1 (NRN1) Neuritin (NRN) Candidate Plasticity Gene 15 (CPG15) Neuritin (NRN1) is a GPI-anchored neurotrophic factor, which is expressed in response to induction of neuronal activity by GDNF, BDNF, NT3 and other neural stimulators. It promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. NRN1 also promotes angiogenesis. During early brain development, NRN1 inhibits apoptosis of cortical progenitors by preventing activation of caspase 3. Recombinant human neuritin is a covalently disulfide-linked homodimer, consisting of two 9.7 kDa polypeptide monomers, each containing 88 amino acid residues.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~19.4 kDa (2x 88 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The ED50as determined by by a cell proliferation assay using rat C6 cells is less than 25 ng/ml, corresponding to a specific activity of >4.0x104IU/mg.