MDK, Rat

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Rat Midkine (MDK) Neurite Growth-Promoting Factor 2 (NEGF2) Amphiregulin-Associated Protein (ARAP) Midgestation and Kidney Protein (MK) MK1Midkine (MDK) is a heparin-binding growth factor that is expressed in various cell types during embryo development and in a variety of carcinomas. It is induced by retinoic acid, as well as during oncogenesis, inflammation, and tissue repair. MDK is pleiotropic and promotes angiogenesis, neurogenesis, chondrogenesis, cell growth, cell migration, and tumorigenesis. It also inhibits apoptosis in some cells. MDK acts through several different receptors including PTP, ALK, PTP-zeta, and LRP. MDK shows significant homology to pleiotrophin (PTN) . The amino acid sequence of Rat MDK is 99% homologous to human MDK.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~13.2 kDa (120 amino acids) Purity: >97% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 10-100 ng/ml.